GASL-Award of the YAEL foundation / YAEL-Stiftung

GASL-Award of the YAEL foundation

The GASL-Award of the YAEL foundation is granted each year at the occasion of the annual congress of the German Association for the Study of the Liver (GASL). The price, which is donated annually with 3,000 €, is awarded by the board and programme committee of the GASL to honour the best scientific publication of the previous year.

Laureates 2024

In 2024, the GASL-price of the YAEL Foundation has been awarded at the Annual Meeting of the German Society for the Study of the Liver (GASL) to JNatascha Röhlen for her publication entitled “Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment”.

Laureate 2024

Dr. Dr. Natascha Röhlen

Academic Career
since 2021: Resident, Klinik für Innere Medizin II – Universitätsklinikum Freiburg
2018 – 2023: PhD at the University Strasbourg, Ecole doctorale des Sciences de la vie et de la Santé (ED414) on: “The functional role of Claudin-1 as a mediator and therapeutic target in liver fibrogenesis and hepatocarcinogenesis”
2013 – 2018: MD at the Universitätsklinikum Freiburg on: “Die Bedeutung des Vitamin D-Sirtuin1-Forkheadbox-Protein O3a-Signalweges in der Pathogenese autoimmuner und maligner Schilddrüsenerkrankungen“

Education
2009 – 2015: Study of Medicine, Goethe Universität Frankfurt

selected publications
1. Roehlen N, Stoehr F, Müller L, Luxenburger H, Gairing SJ, Reincke M, Schultheiss M, Berisha F, Weinmann A, Foerster F, Marquardt JU, Thimme R, Galle PR, Bettinger D, Kloeckner R. Prediction of postembolization syndrome after transarterial chemoembolization of hepatocellular carcinoma and ist impact on prognosis. Hepatol Commun. 2023 Sep 27;7(10):e0252
2. Roehlen N, Muller M, Jühling F, Nehme Z, Cherradi S, Duong FHT, Almeida N, Del Zompo F, Crouchet E, Saviano A, Fernández-Vaquero M, Riedl T, El Saghire H, Durand S, Ponsolles C, Oudot M, Martin R, Brignon N, Felli E, Pessaux P, Davidson I, Bandiera S, Thumann C, Marchand P, Nicolay B, Bardeesy N, Hoshida Y, Laquerriere P, Heikenwälder M, Iacone R, Toso A, Meyer M, Elson G, Schweighoffer T, Schuster C, Mailly L, Lupberger J, Baumert TFB.. A humanized Claudin-1-specific monoclonal antibody for treatment of hepatocellular carcinoma. J Hepatol. 2023 Feb;78(2):343-355.
3. Roehlen N*, Saviano A*, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, Jühling F, Oudot MA, Durand SC, Duong FHT., Cherradi S, Gonzalez Motos V, Almeida N, Ponsolles C, Heydmann L, Ostyn T, Lallement A, Pessaux P, Felli E, Cavalli A, Sgrignani J, Thumann C, Koutsopoulos O, Fuchs BC, Hoshida Y, Hofmann M, Vyberg M, Viuff BM, Galsgaard ED, Elson G, Toso A, Meyer M, Iacone R, Schweighoffer T, Teixeira G, Moll S, De Vito C, Roskams T, Davidson I, Heide D, Heikenwälder M, Zeisel MB, Lupberger J, Mailly L , Schuster C, Baumert TF. A monoclonal antibody targeting non-junctional Claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity. Sci. Trans. Med. 2022 Dec 21;14(676):eabj4221. *shared first-authorship.
4. Roehlen N*, Laubner K*, Nicolaus L, Schwacha H, Bettinger D, Krebs A, Thimme R, Seufert J. Impact of duodenal-jejunal bypass liner (DJBL) on NAFLD in patients with obesity and type 2 diabetes mellitus. Nutrition 2022 Nov-Dec;103-104:111806. *shared first-authorship.